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GUT FEELINGS: Red and processed meat raise your heart disease risk, now scientists know why

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Unlike vegetables, fruits, whole grains, nuts, seeds and beans which are microbiome-friendly, when gut bacteria digests red meat, they produce a chemical called TMAO, which can spur inflammation and blood clotting.

AMY NORTON: A daily hamburger might raise the risk of developing heart disease, but not necessarily for the reasons people often think, new research suggests. The study of nearly 4,000 older Americans found what many have before: People who ate a lot of red meat had a heightened risk of heart disease and stroke.

But there was no evidence that the link was due to a traditional culprit: elevated blood levels of “bad” cholesterol. Instead, researchers traced the risk, in part, to particular substances produced by the gut microbiome — the trillions of bacteria that reside in the digestive tract. When those bacteria digest red meat, they produce a chemical called TMAO, which can spur inflammation and blood clotting…

The study — published online Aug. 1 in the journal Arteriosclerosis, Thrombosis, and Vascular Biology — involved 3,931 U.S. adults aged 65 and older. All had their health and lifestyle habits tracked over time, for up to 26 years…

Meng Wang, a postdoctoral fellow at Tufts University’s Friedman School of Nutrition Science and Policy in Boston, was one of the study leaders… Overall, Wang’s team found, the more red meat people consumed, the higher their risk of suffering a heart attack or stroke. On average, the risk rose by 22% for every daily serving of red meat. That was with other factors, like body weight, smoking, exercise and other eating habits, taken into account.

When researchers looked for potential explanations, they found that higher blood sugar partly accounted for the link between red meat and heart trouble — as did markers of general inflammation in the body. How does higher blood sugar fit in? It’s unclear, but the researchers speculate that the iron in red meat might be one reason. High iron intake has been tied to an increased risk of diabetes.

There was also a third explanation: Three chemicals produced by gut bacteria accounted for about 10% of the association between red meat and cardiovascular disease. Those chemicals included TMAO and two precursors to it — all of which are churned out when gut bacteria break down L-carnitine, a nutrient abundant in red meat. Previous research has shown that TMAO can promote blood vessel inflammation and blood clotting.

“This study gives us a new look into the ‘why’ we should limit red and processed meats in our diets,” said Whitney Linsenmeyer, an assistant professor at Saint Louis University who reviewed the findings. Recent studies have been revealing the importance of the gut microbiome to human health, noted Linsenmeyer, who is also a spokeswoman for the Academy of Nutrition and Dietetics. “So it’s no surprise that there is also a link to heart health,” she said.

Like Gardner, Linsenmeyer said that for the everyday person, it all comes back to diet. Fortunately, the same eating habits that are considered heart-friendly may also support a healthy gut. “Vegetables, fruits, whole grains, nuts, seeds and beans get a gold star for being heart healthy,” Linsenmeyer said. “And they get a second gold star for being microbiome-friendly”. SOURCE…